HUMAN TUMOUR XENOGRAFTING AND RADIOIMMUNOTARGETTING

HUMAN TUMOUR XENOGRAFTING AND RADIOIMMUNOTARGETTING

The transplantability of human tumours especially breast carcinoma as xenografts has been examined in Swiss albino mice that had been immune-suppressed. Tumour takes have been noticed as early as on the eleventh day. Tumour targetting which has assumed great importance both for radioimmunodetection...

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Bibliographic Details
Published in:Current science (Bangalore) Vol. 57; no. 3; pp. 121 - 125
Main Authors: HAZRA, D. K., LAHIRI, V. L., ELHENCE, I. P., SARAN, SHABAD, AGARWAL, M. C.
Format: Journal Article
Language:English
Published: CURRENT SCIENCE ASSOCIATION 05-02-1988
Subjects:
Animals
Antibodies
Cellular immunity
Heterologous transplantation
Humans
Imaging
Lesions
Liver
Monoclonal antibodies
Neoplasia
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Summary:The transplantability of human tumours especially breast carcinoma as xenografts has been examined in Swiss albino mice that had been immune-suppressed. Tumour takes have been noticed as early as on the eleventh day. Tumour targetting which has assumed great importance both for radioimmunodetection as well as radioimmunotherapy has been achieved in these models using 125I labelled anti-HMFG-2 monoclonal antibodies. Such an immune-suppressed model is feasible and economical as compared to athymic nude mice.
ISSN:0011-3891