Transfer of S-1108 from serum to lung tissue and bile juice

• Published in: CHEMOTHERAPY Vol. 41; no. Supplement1; pp. 138 - 143
• Main Authors: Inoue, Fumiyuki, Kamikawa, Yasuaki, Funaki, Naoto, Ishii, Yasunori, Ishizuka, Shinji, Shin, Takanori, Muramatsu, Tomoyoshi, Okabayashi, Takahiro, Hizuta, Akio, Orita, Kunzo
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 30-06-1993
• DOI: 10.11250/chemotherapy1953.41.Supplement1_138
• EISSN: 1884-5894
• ISSN: 0009-3165

The aim of this study was to determine the transfer of the antibiotic, S-1108, administered orally, from serum to lung tissue and bile juice. In sixteen patients with lung diseases, 200mg of S-1108 was given just before surgery. In four patients with biliary diseases, it was given about two weeks after cholecystectomy and T-tube drainage. The concentration of S-1006 in serum, lung tissue and bile juice was determined at intervals of 1, 2, 4, 6, 8 and 12 hr after administration of S-1108. The concentration of S-1006 in serum was 0.49μg/ml 1 hour later, reached a maximum of 0.72μg/ml 2 hours later, and gradually decreased to 0.14μg/ml 12 hours later. The mean rates of transfer of S-1108 from serum to lung tissue and bile juice during the 12 hours after oral administration were 44.1% and 548.9%, respectively. S-1108 appeared to be useful for treatment of lung and biliary tract infections.