Association of Unilateral Massive Hydronephrosis with Hypertension and Erythrocytosis : A Case Report

• Published in: Nihon Jinzo Gakkai shi Vol. 24; no. 9; pp. 1065 - 1073
• Main Authors: Honjo, Akira, Shimasaki, Hideki, Hifumi, Senshu, Tofuku, Yohei, Kuroda, Mitsuhiko, Takeda, Rhoyu, Uchida, Kenzo, Morimoto, Shinpei, Katsumi, Tetsuo, Matsubara, Fujitsugu
• Format: Journal Article
• Language: Japanese
• Published: Japan Japanese Society of Nephrology 01-09-1982
• Subjects: Animals; Erythropoietin - blood; Humans; Hydronephrosis - complications; Hydronephrosis - surgery; Hypertension - etiology; Male; Middle Aged; Nephrectomy; Polycythemia - etiology; Renin - blood
• ISSN: 0385-2385; 1884-0728
• DOI: 10.14842/jpnjnephrol1959.24.1065

A 51 year-old hypertensive man with a unilateral hydronephrosis and erythrocytosis is described. The preoperative peripheral plasma renin activity was normal and the renal vein renin ratio was 1.6. Erythropoietin level in plasma was slightly elevated. After nephrectomy, his blood pressure returned to normal and his erythrocytosis had complete remission for more than two years. In the preoperative period, the angiotensin II analogue infusion indused a rise in blood pressure on normal sodium diet, while the administration of SQ 14225, 12.5mg, p. o. did a reduction in blood pressure under the same diet. After operation, the plasma renin activity changed from normal to a lower value with the concomitant fall in blood pressure. These findings suggest that a normal value of peripheral plasma renin activity in our case may still be inappropriately high in his blood pressure regulation.