A clinical study of cefotaxime in patients with infections complicating a disorder of the hemopoietic tissue. Its therapeutic effect and influence on the coagulation system

• Published in: Japanese journal of antibiotics Vol. 38; no. 11; p. 3145
• Main Authors: Kaneko, H, Shirai, T, Katoh, M, Shimura, H, Nojima, Z, Senzui, N
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-11-1985
• Subjects: Adult; Aged; Bacterial Infections - drug therapy; Blood Coagulation - drug effects; Cefotaxime - pharmacology; Cefotaxime - therapeutic use; Drug Evaluation; Female; Humans; Infusions, Parenteral; Leukemia - blood; Leukemia - complications; Lymphoma - complications; Male; Middle Aged; Multiple Myeloma - complications; Partial Thromboplastin Time; Prothrombin Time
• ISSN: 0368-2781
• DOI: 10.11553/antibiotics1968b.38.3145

Twenty infectious episodes were caused mainly by Gram-negative rods in 16 patients with a disorder of the hemopoietic tissue. The ages of the patients ranged between 20 and 76 years. Cefotaxime (CTX) was used alone in 9 infectious episodes (group I) and in combination with other antibiotics in the remaining 11 infectious episodes (group II). The following results were obtained. A good response to CTX was noted. The clinical and bacteriological success rates were 100% and 83% in group I, and 82% and 100% in group II, respectively. Bleeding was not clinically found during and after treatment of any infectious episodes with CTX. No change in PT and aPTT was noted during CTX treatment, either. CTX was thus evaluated to be an effective and safe cephem antibiotic in the treatment of infectious episodes secondary to a disorder of the hemopoietic tissue, which is usually accompanied by a marked hemorrhagic tendency.