Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress

Summary Inducible HSP70 (HSP70i) chaperones peptides from stressed cells, protecting them from apoptosis. Upon extracellular release, HSP70i serves an adjuvant function, enhancing immune responses to bound peptides. We questioned whether HSP70i differentially protects control and vitiligo melanocyte...

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Bibliographic Details
Published in:	Pigment cell and melanoma research Vol. 27; no. 2; pp. 209 - 220
Main Authors:	Mosenson, Jeffrey A., Flood, Kelsey, Klarquist, Jared, Eby, Jonathan M., Koshoffer, Amy, Boissy, Raymond E., Overbeck, Andreas, Tung, Rebecca C., Le Poole, I. Caroline
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-03-2014 Wiley Subscription Services, Inc
Subjects:	Adolescent Adult autoimmune Cell Survival - drug effects Female heat shock protein HSP70 Heat-Shock Proteins - secretion Humans Hydroquinones - pharmacology Infant, Newborn Intracellular Space - drug effects Intracellular Space - metabolism Male Medical research melanocyte Melanocytes - drug effects Melanocytes - metabolism Melanocytes - pathology Melanosomes - drug effects Melanosomes - metabolism Melanosomes - ultrastructure Microscopy Middle Aged Phenols - pharmacology Protein Transport - drug effects Skin - drug effects Skin - pathology Skin - secretion stress Stress, Physiological - drug effects Subcellular Fractions - drug effects Subcellular Fractions - metabolism Vitiligo Vitiligo - metabolism Vitiligo - pathology Young Adult vitiligo stress heat shock protein autoimmune melanocyte
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