Hypovitaminosis D in patients with cystic fibrosis: a cross-section study in South Brazil

• Published in: The clinical respiratory journal Vol. 8; no. 4; p. 455
• Main Authors: Marcondes, Natália Aydos, Raimundo, Fabiana Viegas, Vanacor, Roberta, Corte, Bruno Pellini, Ascoli, Aline Maria, de Azambuja, Aline Zimmermann, Scopel, Luciano, Dos Santos, Patrícia Vargas, Dalcin, Paulo de Tarso Roth, Rotta, Liane Nanci, Furlanetto, Tania Weber, Faulhaber, Gustavo Adolpho Moreira
• Format: Journal Article
• Language: English
• Published: England 01-10-2014
• Subjects: Adolescent; Adult; Body Mass Index; Brazil; Cross-Sectional Studies; Cystic Fibrosis - blood; Cystic Fibrosis - complications; Female; Hospitalization; Humans; Male; Prevalence; Risk Factors; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - diagnosis; Vitamin D Deficiency - epidemiology; Young Adult; pulmonary function; nutrition; 25-hydroxyvitamin D; cystic fibrosis; vitamin D deficiency
• ISSN: 1752-699X
• DOI: 10.1111/crj.12097

Cystic fibrosis (CF) patients have a susceptibility to vitamin D deficiency because of nutrient malabsorption.
To evaluate the prevalence of hypovitaminosis D in CF patients and the factors associated with serum 25-hydroxyvitamin D levels.
We evaluated the prevalence of vitamin D deficiency defined as 25-hydroxyvitamin D <30 ng/mL, as suggested recently by the Cystic Fibrosis Foundation, and factors associated with its serum levels. Patients with confirmed CF were included. Nutritional status and hospital admissions were evaluated. Serum C-reactive protein, calcium, phosphate, magnesium, albumin, 25-hydroxyvitamin D and parathyroid hormone levels were measured. Lung function was evaluated by spirometry, and clinical and chest radiographic scores were assessed. Statistical significance level was set at P < 0.05.
Fifty-nine patients were included. Prevalence of hypovitaminosis D was 61%. Patients with pancreatic insufficiency had a trend to have higher vitamin D levels. Sixteen patients had severe lung disease with percentage of forced expiratory volume in 1 s predicted below 40%. After multivariate analysis, body mass index and hospitalization in the last month remained significantly associated with serum vitamin D levels.
Vitamin D insufficiency is still a problem in CF patients, even in those receiving supplementation.