Thymic carcinosarcoma with melanocytic differentiation in a dog

Carcinosarcomas are very rare tumors in dogs. Although carcinosarcomas with melanocytic differentiation arising from organs other than the thymus have been described in humans, this type of tumor has not been reported in dogs in any part of the body. We observed such a tumor in the cranial mediastin...

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Bibliographic Details
Published in:	Canadian veterinary journal Vol. 65; no. 7; pp. 661 - 666
Main Authors:	Pollet, Valentine, Picavet, Pierre P., Heimann, Marianne, Hamaide, Annick
Format:	Journal Article Web Resource
Language:	English
Published:	Canada Canadian Veterinary Medical Association 01-07-2024
Subjects:	Animals Carcinosarcoma Carcinosarcoma - diagnosis Carcinosarcoma - pathology Carcinosarcoma - surgery Carcinosarcoma - veterinary Dog Diseases Dog Diseases - diagnosis Dog Diseases - pathology Dog Diseases - surgery Dogs Fatal Outcome Female Life sciences Medicine (all) Melanocytes Melanocytes - pathology Médecine vétérinaire & santé animale Sciences du vivant Scientific Thymus Neoplasms Thymus Neoplasms - diagnosis Thymus Neoplasms - pathology Thymus Neoplasms - surgery Thymus Neoplasms - veterinary Veterinary medicine & animal health
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Summary:	Carcinosarcomas are very rare tumors in dogs. Although carcinosarcomas with melanocytic differentiation arising from organs other than the thymus have been described in humans, this type of tumor has not been reported in dogs in any part of the body. We observed such a tumor in the cranial mediastinum of an 11-year-old spayed female dachshund. The dog was admitted to the clinic because of coughing, sporadic regurgitation, and dyspnea. Thoracic ultrasonography and computed tomography revealed a large mediastinal mass that was surgically removed via sternotomy. The tumor was of thymic origin and demonstrated 3 distinct components: an epithelial component positive for pancytokeratin (AE1/AE3) and high molecular weight cytokeratin (CK5/CK6) with some cystic spaces; a mesenchymal component positive for vimentin; and in association with the epithelial part, a minor melanocytic component positive for Melan A. Histologic metastasis of the epithelial and melanocytic components was present within a tracheobronchial lymph node. The dog died 105 d after surgery, after an episode of acute dyspnea.Key clinical message:To the authors' knowledge, this is the first report of thymic carcinosarcoma with melanocytic differentiation.
Bibliography:	0008-5286(20240701)65:7L.661;1- ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 scopus-id:2-s2.0-85197717626
ISSN:	0008-5286