Impact of Helicobacter pylori on the clinical course of recurrent aphthous stomatitis

• Published in: Journal of oral pathology & medicine Vol. 42; no. 1; pp. 89 - 94
• Main Authors: Arslan Taş, Didem, Yakar, Tolga, Sakalli, Hakan, Serin, Ender
• Format: Journal Article
• Language: English
• Published: Frederiksberg Blackwell Publishing Ltd 01-01-2013; Wiley
• Subjects: Adult; Aphthous stomatitis; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Biopsy; Chi-Square Distribution; Dentistry; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; Helicobacter pylori; Helicobacter pylori - pathogenicity; Human bacterial diseases; Humans; Infectious diseases; Male; Medical sciences; Middle Aged; Mucosa; Non tumoral diseases; Otorhinolaryngology. Stomatology; recurrent aphthous stomatitis (RAS); Statistics, Nonparametric; Stomatitis, Aphthous - microbiology; Urea; Vitamin B 12; Vitamin B 12 - blood; Vitamin B12; Relapse; Spirillales; Stomatology; Vitamin; Spirillaceae; ENT; recurrent aphthous stomatitis (RAS); Aphta; Cyanocobalamin; Stomatitis; Helicobacter pylori; Vitamin B; Bacteria; Oral cavity disease
• ISSN: 0904-2512; 1600-0714
• DOI: 10.1111/j.1600-0714.2012.01197.x

Background
Recurrent aphthous stomatitis is one of the most common lesions of oral mucosa. Helicobacter pylori is suggested as one of the etiological agents of recurrent aphthous stomatitis. Here, we conduct a study for evaluating the impact of H. pylori eradication on clinical course of recurrent aphthous stomatitis.
Methods
Forty‐six patients with minor aphthous lesions were enrolled. The number of RAS lesions at last 6 months and vitamin B12 levels were recorded. All patients were detected for H. pylori with endoscopic biopsy. H. pylori was positive in 30 patients and negative in 16 patients. H. pylori‐positive 30 patients received eradication therapy. Three months after therapy, patients were re‐evaluated with urea breath test; 18 patients were negative (eradicated), and the remainders (12 patients) were positive (non‐eradicated) for H. pylori. 6 months after eradication, vitamin B12 levels and number of aphthous lesions at 6 months were recorded.
Results
Vitamin B12 levels were significantly increased in H. pylori‐eradicated group (P = 0.001), whereas no significant change was found in non‐eradicated group (P = 0.638). Mean number of aphthous lesions (per 6 months) of H. pylori‐eradicated group was significantly decreased after eradication (P = 0.0001); in the non‐eradicated group, no significant change was found (P = 0.677). In Hp‐positive group, number of RAS lesions and vitamin B12 levels were negatively correlated when evaluated both before and after eradication.
Conclusions
This study provides evidence to support the beneficial effect of H. pylori eradication in patients with recurrent aphthous stomatitis. The underlying mechanism might be the increase in vitamin B12 levels after eradication.