N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors

N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors

Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.

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Bibliographic Details
Published in:Pharmazie Vol. 62; no. 8; p. 636
Main Authors: Rakowitz, D, Gmeiner, A, Matuszczak, B
Format: Journal Article
Language:English
Published: Germany 01-08-2007
Subjects:
Acetates - chemical synthesis
Acetates - pharmacology
Aldehyde Reductase - antagonists & inhibitors
Animals
Cattle
Dimethyl Sulfoxide
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Lens, Crystalline - enzymology
Magnetic Resonance Spectroscopy
Quinazolines - chemical synthesis
Quinazolines - pharmacology
Solvents
Spectrometry, Mass, Electrospray Ionization
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Abstract Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.
AbstractList Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.
Author Matuszczak, B
Rakowitz, D
Gmeiner, A
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  surname: Gmeiner
  fullname: Gmeiner, A
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  givenname: B
  surname: Matuszczak
  fullname: Matuszczak, B
BackLink https://www.ncbi.nlm.nih.gov/pubmed/17867563$$D View this record in MEDLINE/PubMed
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Snippet Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl...
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StartPage 636
SubjectTerms Acetates - chemical synthesis
Acetates - pharmacology
Aldehyde Reductase - antagonists & inhibitors
Animals
Cattle
Dimethyl Sulfoxide
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Lens, Crystalline - enzymology
Magnetic Resonance Spectroscopy
Quinazolines - chemical synthesis
Quinazolines - pharmacology
Solvents
Spectrometry, Mass, Electrospray Ionization
Title N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors
URI https://www.ncbi.nlm.nih.gov/pubmed/17867563
Volume 62
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