N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors

Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.

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Bibliographic Details
Published in:	Pharmazie Vol. 62; no. 8; p. 636
Main Authors:	Rakowitz, D, Gmeiner, A, Matuszczak, B
Format:	Journal Article
Language:	English
Published:	Germany 01-08-2007
Subjects:	Acetates - chemical synthesis Acetates - pharmacology Aldehyde Reductase - antagonists & inhibitors Animals Cattle Dimethyl Sulfoxide Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Lens, Crystalline - enzymology Magnetic Resonance Spectroscopy Quinazolines - chemical synthesis Quinazolines - pharmacology Solvents Spectrometry, Mass, Electrospray Ionization
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Description
Summary:	Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, respectively, were synthesized and evaluated as aldose reductase inhibitors.
ISSN:	0031-7144
DOI:	10.1691/ph.2007.8.7520