Transport evaluation of alendronate across Caco-2 cell monolayers

The transport of alendronate through Caco-2 monolayers in the absence and presence of absorption enhancers (sodium taurocholate-STC and dimethyl-beta-cyclodextrin-DM-beta-CD) was studied. The viability of Caco-2 cells was determined by MTT assay. The effects of the experiment period and serum existe...

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Bibliographic Details

Published in:	Pharmazie Vol. 64; no. 2; p. 98
Main Authors:	Karamustafa, F, Celebi, N, Değim, Z, Unal, N
Format:	Journal Article
Language:	English
Published:	Germany 01-02-2009
Subjects:	Absorption Alendronate - pharmacokinetics beta-Cyclodextrins - pharmacology Biological Transport, Active Bone Density Conservation Agents - pharmacokinetics Caco-2 Cells Cell Membrane Permeability - drug effects Cell Survival - drug effects Electric Impedance Excipients Humans Taurocholic Acid - pharmacology Tetrazolium Salts Thiazoles
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