Drug loading of nanoporous TiO2 films

• Published in: Biomedical materials (Bristol) Vol. 1; no. 4; p. L11
• Main Authors: Ayon, Arturo A, Cantu, Michael, Chava, Kalpana, Agrawal, C Mauli, Feldman, Marc D, Johnson, Dave, Patel, Devang, Marton, Denes, Shi, Emily
• Format: Journal Article
• Language: English
• Published: England 01-12-2006
• Subjects: Absorption; Biocompatible Materials - chemistry; Drug Carriers - chemistry; Drug Compounding - methods; Materials Testing; Nanostructures - chemistry; Nanostructures - ultrastructure; Particle Size; Pharmaceutical Preparations - administration & dosage; Pharmaceutical Preparations - chemistry; Pharmaceutical Vehicles - chemistry; Porosity; Titanium - chemistry
• ISSN: 1748-605X
• DOI: 10.1088/1748-6041/1/4/L01

The loading of therapeutic amounts of drug on a nanoporous TiO(2) surface is described. This novel drug-loading scheme on a biocompatible surface, when employed on medical implants, will benefit patients who require the deployment of drug-eluting implants. Anticoagulants, analgesics and antibiotics can be considered on the associated implants for drug delivery during the time of maximal pain or risk for patients undergoing orthopedic procedures. Therefore, this scheme will maximize the chances of patient recovery.