Microsomal prostaglandin E2 synthase-1 in breast cancer: a potential target for therapy

The anti‐tumour actions of cyclooxygenases (COX) are thought to be mediated by inhibition of prostaglandin E2 (PGE2) synthesis. However, COX‐2 inhibition also alters cellular production of other prostaglandins such as prostacyclin (PGI2). The latter action is believed to be important for the develop...

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Bibliographic Details
Published in:	The Journal of pathology Vol. 208; no. 3; pp. 356 - 363
Main Authors:	Mehrotra, Sanjana, Morimiya, Akira, Agarwal, Beamon, Konger, Raymond, Badve, Sunil
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-02-2006
Subjects:	Analysis of Variance Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Blotting, Western - methods breast cancer Breast Neoplasms - chemistry Breast Neoplasms - pathology Carcinoma, Ductal, Breast - chemistry Carcinoma, Ductal, Breast - pathology Case-Control Studies Cell Line Cell Line, Tumor cyclooxygenase Cyclooxygenase 2 - analysis Female Humans Immunohistochemistry - methods Intramolecular Oxidoreductases - analysis Intramolecular Oxidoreductases - genetics Lymphatic Metastasis Male microsomal prostaglandin E2 synthase Middle Aged Prostaglandin-E Synthases Reverse Transcriptase Polymerase Chain Reaction Up-Regulation
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