Neuroengineering Tools For Studying The Effect Of Intracortical Microstimulation In Rodent Models

Neuroengineering Tools For Studying The Effect Of Intracortical Microstimulation In Rodent Models

Intracortical microstimulation can be successfully used to manipulate neuronal activity and connectivity, thus representing a potentially powerful tool to steer neuroplasticity occurring after brain injury. Activity-dependent stimulation (ADS), in which the spikes recorded from a single neuron are u...

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Bibliographic Details
Published in:2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Vol. 2018; pp. 3076 - 3079
Main Authors: Averna, A., Guggenmos, D., Pasquale, V., Semprini, M., Nudo, R., Chiappalone, M.
Format: Conference Proceeding Journal Article
Language:English
Published: United States IEEE 01-07-2018
Subjects:
ADS
Band-pass filters
Brain injuries
closed-Loop Stimulation
DC motors
Firing
ICMS
In vivo
Neurons
plasticity
Rats
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Summary:Intracortical microstimulation can be successfully used to manipulate neuronal activity and connectivity, thus representing a potentially powerful tool to steer neuroplasticity occurring after brain injury. Activity-dependent stimulation (ADS), in which the spikes recorded from a single neuron are used to trigger stimulation at another cortical location, is able to potentiate cortical connections between distant brain areas. Here, we developed an experimental procedure and a computational pipeline aimed at investigating the ability of ADS to induce changes in intra-cortical activity of healthy anesthetized rats.
ISSN:1557-170X
1558-4615
DOI:10.1109/EMBC.2018.8512915