A New Class of Modular Phosphinite-Oxazoline Ligands: Ir-Catalyzed Enantioselective Hydrogenation of Alkenes

A New Class of Modular Phosphinite-Oxazoline Ligands: Ir-Catalyzed Enantioselective Hydrogenation of Alkenes

Both enantiomers are readily prepared of phosphinite–oxazoline ligands 1 from the D and L enantiomers of serine (see Scheme). Iridium complexes derived from these ligands (the structure of one complex is shown) are excellent catalysts for the enantioselective hydrogenation of unfunctionalized alkene...

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Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 40; no. 23; pp. 4445 - 4447
Main Authors: Blankenstein, Jörg, Pfaltz, Andreas
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag GmbH 03-12-2001
WILEY‐VCH Verlag GmbH
Subjects:
asymmetric catalysis
hydrogenation
iridium
ligand design
N,P ligands
P ligands
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Summary:Both enantiomers are readily prepared of phosphinite–oxazoline ligands 1 from the D and L enantiomers of serine (see Scheme). Iridium complexes derived from these ligands (the structure of one complex is shown) are excellent catalysts for the enantioselective hydrogenation of unfunctionalized alkenes. R1=ferrocenyl, aryl; R2=alkyl, benzyl.
Bibliography:istex:4193298EF567A10EC2BD809D9F6DC326860C0B50
ArticleID:ANIE4445
ark:/67375/WNG-71LHK4V4-X
We thank Dr. Martin Studer and Dr. Benoît Pugin (Solvias AG, Basel) for fruitful discussions, and Prof. Kevin Burgess (Texas A&M University) for preprints of related unpublished work. Financial support by the Swiss National Science Foundation is gratefully acknowledged.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20011203)40:23<4445::AID-ANIE4445>3.0.CO;2-V