Wound healing effect of naringin gel in alloxan induced diabetic mice

• Published in: Ankara Üniversitesi Eczacılık Fakültesi dergisi = Journal of Faculty of Pharmacy of Ankara University Vol. 44; no. 3; pp. 397 - 414
• Main Authors: Okur,Mehmet Evren, Şakul,Ayşegül Arzu, Ayla,Şule, Karadağ,Ayşe Esra, Şahin Şenyüz,Cemre, Batur,Şebnem, Daylan,Benay, Özdemir,Ekrem Musa, Palabıyık Yücelik,Şaziye Sezin, Sipahi,Hande, Aydın,Ahmet
• Format: Journal Article
• Language: English
• Published: Ankara Üniversitesi Eczacılık Fakültesi 01-03-2020
• Subjects: Sağlık Hizmetleri; Tıp; Ankara; Türkiye; Cell culture; Hücre kültürü; Naringin; Wound healing; Diabetes mellitus; Yara iyileşmesi; HET-CAM
• ISSN: 1015-3918
• DOI: 10.33483/jfpau.742224

Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.
Material and Method: In vitro direct contact assay and hen’s egg chorio-allantoin membrane tests were used to evaluate irritation, and cytotoxicity potential of Naringin. In vitro antimicrobial activity was also tested. Topical treatments were administered once a day on the wound. Wound lesions were photographed and statistically analyzed. After the 10th day, histopathological parameters of tissues were assessed. Result and Discussion: The results showed that naringin gel has no cytotoxicity and irritation potential. Also, it displayed a weak antimicrobial effect. Aside from these, in vivo studies revealed that naringin gel showed statistically higher wound contraction and re-epithelialization, the thickness of granulation tissue, angiogenesis scores. The results indicated that naringin gel effectively enhanced diabetic wound healing, and so this formulation could be considered a promising therapeutic alternative for treating diabetic wounds.