The Cyclic AMP Response Element Modulator {alpha} Suppresses CD86 Expression and APC Function

The cAMP response element modulator (CREM)alpha is a widely expressed transcriptional repressor that is important for the termination of the T cell immune response and contributes to the abnormal T cell function in patients with systemic lupus erythematosus. We present evidence that APCs of Crem(-/-...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 182; no. 7; pp. 4167 - 4174
Main Authors:	Ahlmann, Martina, Varga, Georg, Sturm, Karsten, Lippe, Ralph, Benedyk, Konrad, Viemann, Dorothee, Scholzen, Thomas, Ehrchen, Jan, Muller, Frank U, Seidl, Matthias, Matus, Marek, Tsokos, George C, Roth, Johannes, Tenbrock, Klaus
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 01-04-2009
Subjects:	Animals Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism B7-2 Antigen - genetics B7-2 Antigen - immunology B7-2 Antigen - metabolism Cyclic AMP Response Element Modulator - genetics Cyclic AMP Response Element Modulator - immunology Cyclic AMP Response Element Modulator - metabolism Dermatitis, Contact - immunology Dermatitis, Contact - pathology Flow Cytometry Gene Expression - immunology Gene Expression Regulation - immunology Humans Lymphocyte Activation - immunology Mice Mice, Transgenic Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes - immunology
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