CD40-CD40L Interactions Induce Chemokine Expression by Human Microglia : Implications for Human Immunodeficiency Virus Encephalitis and Multiple Sclerosis

CD40 is a protein on microglia that is up-regulated with interferon (IFN)-gamma and is engaged by CD40L, found on CD4+ T cells, B cells, and monocytes. These interactions may be important in central nervous system inflammatory diseases. Microglia have been shown to be a source of chemokines, whose e...

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Bibliographic Details
Published in:	The American journal of pathology Vol. 160; no. 2; pp. 559 - 567
Main Authors:	D'Aversa, Teresa G, Weidenheim, Karen M, Berman, Joan W
Format:	Journal Article
Language:	English
Published:	Bethesda, MD ASIP 01-02-2002 American Society for Investigative Pathology
Subjects:	Adolescent Adult Antigens, CD - immunology Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - immunology Antigens, Differentiation, Myelomonocytic - metabolism Biological and medical sciences Brain - pathology Brain - physiopathology CD40 Antigens - immunology CD40 Antigens - metabolism CD40 Ligand - immunology CD40 Ligand - metabolism CD40 Ligand - pharmacology Cells, Cultured Chemokines - genetics Chemokines - immunology Chemokines - metabolism Child Encephalitis, Viral - physiopathology Female HIV Infections - immunology HIV Infections - physiopathology Human viral diseases Humans Infant Infectious diseases Interferon-gamma - pharmacology Male Medical sciences Microglia - drug effects Microglia - immunology Microglia - metabolism Middle Aged Mitogen-Activated Protein Kinases - metabolism Multiple Sclerosis - immunology Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Regular Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Human Immunohistochemistry Immunopathology Encephalitis Nervous system diseases Multiple sclerosis Ligand Pathogenesis AIDS Immune deficiency Cerebral disorder Inflammatory disease Microglia Infection Chemokine Pathology Viral disease Central nervous system disease Molecular biology
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