Cathepsin E expression by normal and premalignant cervical epithelium

We have investigated the expression of the aspartic proteinase cathepsin E and HLA-DR and the presence of HPV16 in normal squamous epithelium (n = 8) and low-grade (n = 21) and high-grade (n = 14) intraepithelial squamous lesions of the uterine cervix. Immunohistochemistry of cervical biopsies revea...

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Bibliographic Details
Published in:	The American journal of pathology Vol. 150; no. 4; pp. 1223 - 1229
Main Authors:	Mota, F, Kanan, JH, Rayment, N, Mould, T, Singer, A, Chain, BM
Format:	Journal Article
Language:	English
Published:	Bethesda, MD ASIP 01-04-1997 American Society for Investigative Pathology
Subjects:	Adolescent Adult Biological and medical sciences Cathepsin E Cathepsins - biosynthesis Cervix Uteri - enzymology Cervix Uteri - immunology Cervix Uteri - pathology Child Child, Preschool Epithelium - enzymology Epithelium - immunology Epithelium - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics HLA-DR Antigens - biosynthesis Humans Infant Medical sciences Palatine Tonsil Papillomaviridae Papillomavirus Infections - enzymology Papillomavirus Infections - immunology Papillomavirus Infections - pathology Precancerous Conditions - enzymology Precancerous Conditions - immunology Precancerous Conditions - pathology Tumor Virus Infections - enzymology Tumor Virus Infections - immunology Tumor Virus Infections - pathology Tumors Uterine Cervical Neoplasms - enzymology Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - pathology Histological grading Immunohistochemistry Pathogenesis In situ HLA-DR-System Major histocompatibility system Papovaviridae Hybridization Papillomavirus Human papillomavirus 16 Human papillomavirus Cervical dysplasia Aspartic endopeptidases Human Premalignant lesion Enzyme Cathepsin E Female genital diseases Virus Polymerase chain reaction Pathology Peptidases Hydrolases Molecular biology Intraepithelial neoplasia Uterine cervix diseases
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