Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion

Human acute leukemia and myelodysplasia are often associated with an interstitial deletion in chromosome arm 5q. The deleted region is hypothesized to contain tumor suppressor loci that are critical to the maintenance of normal hematopoiesis. We have identified NKIAMRE, a novel cyclin-dependent kina...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 59; no. 16; pp. 4069 - 4074
Main Authors:	MIDMER, M, HAQ, R, SQUIRE, J. A, ZANKE, B. W
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 15-08-1999
Subjects:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences Chromosome Deletion Chromosome Mapping Chromosomes, Human, Pair 5 Cloning, Molecular Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism Hematologic and hematopoietic diseases Humans Leukemia - enzymology Leukemia - genetics Leukemia - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Molecular Sequence Data Rats Sequence Alignment Sequence Homology, Amino Acid Chromosomal aberration Genetic mapping Human Rat Enzyme Transferases Acute Leukemia Rodentia Cyclin Malignant hemopathy Vertebrata Mammalia Abnormal chromosome B5 Protein kinase Animal Deletion Abnormal chromosome Genetics Locus Tumor cell Tumor suppressor gene
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Summary:	Human acute leukemia and myelodysplasia are often associated with an interstitial deletion in chromosome arm 5q. The deleted region is hypothesized to contain tumor suppressor loci that are critical to the maintenance of normal hematopoiesis. We have identified NKIAMRE, a novel cyclin-dependent kinase-related molecule that is closely related to the rat serine/threonine kinase NKIATRE. Human NKIAMRE localizes to chromosome band 5q31.1, centromeric to the interleukin 9 locus and telomeric to IFN response factor-1. NKIAMRE was deleted at both alleles in 9 of 18 leukemic samples with chromosome band 5q31 abnormalities studied by fluorescence in situ chromosomal hybridization. NKIAMRE loss may be an important determinant of dysmyelopoiesis.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0008-5472 1538-7445