Interleukin 1 receptor antagonist inhibits the augmentation of metastasis induced by interleukin 1 or lipopolysaccharide in a human melanoma/nude mouse system

This study examined the ability of the recombinant human interleukin 1 receptor antagonist (IL-1ra) to block interleukin 1 (IL-1)-mediated experimental metastases from the A375M human melanoma. In vivo, IL-1ra administrated at concentrations > or = 200 times IL-1 significantly inhibited the incre...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 53; no. 20; pp. 5051 - 5054
Main Authors:	CHIRIVI, R. G. S, GAROFALO, A, PADURA, M, MANTOVANI, A, GIAVAZZI, R
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 15-10-1993
Subjects:	Animals Anticarcinogenic Agents - therapeutic use Biological and medical sciences Cell Line Dissemination Female Humans Interleukin 1 Receptor Antagonist Protein Interleukin-1 - toxicity Lipopolysaccharides - toxicity Lung Neoplasms - prevention & control Lung Neoplasms - secondary Medical sciences Melanoma - pathology Mice Mice, Nude Neoplasm Metastasis - prevention & control Recombinant Proteins - therapeutic use Recombinant Proteins - toxicity Sialoglycoproteins - therapeutic use Transplantation, Heterologous Tumor cell Tumor Cells, Cultured Tumors Antineoplastic agent Animal model Intravenous administration Cytokine Antimetastatic agent Metastasis Potential Malignant tumor In vitro In vivo Treatment Immunotherapy Interleukin 1 Established cell line Metastatic Antagonist Inhibition Tumor cell Biological receptor
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