Herpes simplex encephalitis: treatment with surgical decompression and cytosine arabinoside

Herpes simplex encephalitis in a 21-year-old man presented as a flu-like illness, followed by inappropriate behaviour, drowsiness and focal neurologic signs. Investigations indicated a lesion in the right temporal lobe. The diagnosis was confirmed by isolation of the virus from a cerebral biopsy. Pr...

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Bibliographic Details
Published in:	Canadian Medical Association journal Vol. 115; no. 3; pp. 236 - 237
Main Authors:	Laha, R. K, Saunders, F. W, Huestis, W. S
Format:	Journal Article
Language:	English
Published:	Canada Can Med Assoc 07-08-1976
Subjects:	Adult Craniotomy Cytarabine - therapeutic use Encephalitis - drug therapy Encephalitis - surgery Encephalitis - therapy Herpes Simplex - drug therapy Herpes Simplex - therapy Humans Intracranial Pressure Male
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Summary:	Herpes simplex encephalitis in a 21-year-old man presented as a flu-like illness, followed by inappropriate behaviour, drowsiness and focal neurologic signs. Investigations indicated a lesion in the right temporal lobe. The diagnosis was confirmed by isolation of the virus from a cerebral biopsy. Pronounced clinical improvement was noted when cytosine arabinoside therapy was started in the postoperative period. This report supports the observation by some authors that cytosine arabinoside may be of value in the treatment of herpes simplex encephalitis.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0008-4409