Properties of Bisphosphonates in the 13762 Rat Mammary Carcinoma Model of Tumor-Induced Bone Resorption

Bone metastasis from primary tumors is a clinically important complication of neoplastic progression. The role of parathyroid hormone-related protein (PTHrP) and transforming growth factor (TGF)-β1 in this process has been clearly established. The current study describes an in vivo model of 13762 ra...

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Bibliographic Details
Published in:	Clinical cancer research Vol. 9; no. 15; pp. 5705 - 5713
Main Authors:	ALVAREZ, Enrique, WESTMORE, Michael, ZAMBRANO, Carmen, MA, Linda, SATO, Masahiko, MARTIN, T. John, TEICHER, Beverly A, GALBREATH, Elizabeth J, SELLS GALVIN, Rachelle J, CLAPP, Crystal L, CONSIDINE, Eileen L, SMITH, Shawn J, KEYES, Kristan, IVERSEN, Philip W, DELAFUENTE, Dawn M, SULAIMON, Shola
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 15-11-2003
Subjects:	Animals Antineoplastic agents Antineoplastic Agents - toxicity Biological and medical sciences Bone Resorption - etiology Bone Resorption - prevention & control Cell Division - drug effects Cell Line, Tumor Cell Survival - drug effects Chemotherapy Diphosphonates - therapeutic use Disease Progression Female Humans Mammary Neoplasms, Experimental - complications Mammary Neoplasms, Experimental - drug therapy Medical sciences Neoplasm Metastasis Osteolysis - etiology Osteolysis - prevention & control Parathyroid Hormone-Related Protein - analysis Parathyroid Hormone-Related Protein - genetics Pharmacology. Drug treatments Rats Rats, Inbred F344 Transforming Growth Factor beta - analysis Transforming Growth Factor beta - genetics Antineoplastic agent Carcinoma Rat Rodentia Resorption Diphosphonic acid derivatives Antimetastatic agent Malignant tumor Metastasis Osteolysis Bisphosphonates Mammary gland diseases Vertebrata Chemotherapy Mammalia Treatment Animal Subcutaneous administration Metastatic Mammary gland Bone
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