Joint biomarkers in idiopathic femoral head osteonecrosis: comparison with hip osteoarthritis

• Published in: Journal of rheumatology Vol. 32; no. 8; pp. 1518 - 1523
• Main Authors: KATO, Shinichi, YAMADA, Harumoto, TERADA, Nobuki, MASUDA, Koichi, LENZ, Mary Ellen, MORITA, Mitsuhiro, YOSHIHARA, Yasuo, HENMI, Osamu
• Format: Journal Article
• Language: English
• Published: Toronto, ON The Journal of Rheumatology 01-08-2005; Journal of Rheumatology Publishing
• Subjects: Biological and medical sciences; Biomarkers; Cartilage - metabolism; Cartilage - pathology; Cartilage Oligomeric Matrix Protein; Diseases of the osteoarticular system; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix Proteins - metabolism; Femur Head Necrosis - metabolism; Femur Head Necrosis - pathology; Glycoproteins - metabolism; Humans; Hyaluronic Acid - metabolism; Joints - metabolism; Joints - pathology; Keratan Sulfate - metabolism; Matrilin Proteins; Medical sciences; Miscellaneous. Osteoarticular involvement in other diseases; Osteoarthritis; Osteoarthritis, Hip - metabolism; Osteoarthritis, Hip - pathology; Synovial Fluid - metabolism; Vascular bone diseases; Steroid; Femoral head; Keratan sulfate; Diseases of the osteoarticular system; Biological marker; Osteonecrosis; Cartilage; Synovial fluid; Healing agent; Hip osteoarthritis; Degenerative disease; Antirheumatic agent; Hip joint; Human; Idiopathic; Concentration; Joint; Metabolism; Hip; Protein; Treatment; Arthropathy; Hyaluronic acid; Osteoarthritis; Comparative study; JOINT BIOMARKERS CARTILAGE OLIGOMERIC MATRIX PROTEIN OSTEONECROSIS OSTEOARTHRITIS SYNOVIAL FLUID ELISA
• ISSN: 0315-162X; 1499-2752

OBJECTIVE: To compare concentrations of joint biomarkers in synovial fluid (SF) between idiopathic osteonecrosis of the femoral
head (ION) and osteoarthritis (OA) of the hip joint. METHODS: Levels of the joint biomarkers cartilage oligomeric matrix protein
(COMP), antigenic keratan sulfate (AgKS), and hyaluronan (HA) in SF samples from 21 cases of ION and their relationship to
disease stage and history of steroid use were assessed and compared to the result of 29 cases of hip OA. RESULTS: In both
the ION and hip OA groups, levels of COMP and AgKS in SF showed a significant positive correlation. The ION group had significantly
higher levels of AgKS in SF than the hip OA group. In the ION group, stage II patients had significantly higher SF levels
of both COMP and AgKS than those in stage III patients. No difference in level of HA in hip joint SF was found between steroid
and non-steroid treated ION patients or between the stage II and III subgroups. CONCLUSION: SF levels of COMP and AgKS may
serve as useful joint biomarkers that reflect cartilage metabolism not only in hip OA but also in ION.