Effects of retinoids on metabolizing enzymes and on binding of benzo(a)pyrene to rat tissue DNA

Retinyl acetate, 13-cis-retinoic acid (13cisRA), and N-(4-hydroxyphenyl)-retinamide (4HPR) were assayed for their in vivo effects on hepatic levels of cytochrome P450, cytosolic glutathione-S-transferase, and quinone reductase. When given p.o. to Sprague-Dawley rats, all of the retinoids caused sign...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 47; no. 19; pp. 5014 - 5020
Main Authors:	MCCARTHY, D. J, LINDAMOOD III, C, HILL, D. L
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 01-10-1987
Subjects:	Animals Aryl Hydrocarbon Hydroxylases - biosynthesis Azo Compounds - pharmacology Benzo(a)pyrene - metabolism Biological and medical sciences Butylated Hydroxytoluene - pharmacology Carcinogenesis, carcinogens and anticarcinogens Chemical agents Cytochrome P-450 Enzyme System - biosynthesis DNA - metabolism Dose-Response Relationship, Drug Glutathione Transferase - biosynthesis Isoenzymes - analysis Male Medical sciences Molecular Weight Quinone Reductases - biosynthesis Rats Retinoids - pharmacology Tumors Rat Cytochrome P450 Interaction Rodentia Retinoids Polycyclic aromatic compound Metabolism Carcinogen In vivo Vertebrata Mammalia Glutathione transferase Animal Carcinogenesis initiation
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