Synchronous Collecting Duct Carcinoma and Papillary Renal Cell Carcinoma: A Case Report and Review of the Literature

• Published in: Anticancer research Vol. 25; no. 1B; pp. 579 - 586
• Main Authors: MATEI, Deliu-Victor, ROCCO, Bernardo, VARELA, Rodolfo, VERWEIJ, Fabrizio, SCARDINO, Epifanio, RENNE, Giuseppe, DE COBELLI, Ottavio
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01-01-2005
• Subjects: Aged; Biological and medical sciences; Carcinoma - complications; Carcinoma - diagnosis; Carcinoma, Renal Cell - complications; Carcinoma, Renal Cell - diagnosis; Disease-Free Survival; Humans; Immunohistochemistry; Kidney - pathology; Kidney Neoplasms - diagnosis; Kidney Neoplasms - pathology; Kidney Tubules, Collecting - pathology; Kidneys; Male; Medical sciences; Neoplasms, Multiple Primary - diagnosis; Nephrology. Urinary tract diseases; Receptor, ErbB-2 - biosynthesis; Time Factors; Tomography, X-Ray Computed; Tumors; Tumors of the urinary system; Kidney disease; Case study; Synchronous collecting duct carcinoma; Urinary system disease; Cancerology; Papillary carcinoma; papillary renal cell carcinoma; Urinary system; Grawitz tumor; Malignant tumor; Collecting duct; Bibliographic review
• ISSN: 0250-7005; 1791-7530

The coexistence of multiple and synchronous primary neoplasms in the same organ (including kidney) has only rarely been described
in the literature. We herein present a case of collecting duct carcinoma (CDC) combined with papillary renal carcinoma (RCC)
having a 57-month disease-free survival. CDC is a rather rare and aggressive neoplasm of the kidney. Sharing probably the
same embryological origin, synchronous or metachronous association with in situ or papillary transitional cell carcinoma (TCC)
may be found; association with RCC has been only once reported in the literature. The high incidence of c-erbB-2 oncogene
amplification in CDC further characterizes this tumor as a separate entity from renal cell carcinoma, and shows some genetic
characteristics in common with TCC. The histological diagnosis of Bellini CDC can be confirmed by the positive immunohistochemical
staining with a collecting duct marker and distal tubule marker and negative staining with a proximal tubule marker.