Metabolism of alachlor by rat and mouse liver and nasal turbinate tissues

The metabolism of alachlor was studied using in vitro incubations with microsomal fractions prepared from liver and nasal turbinates of rats and mice. Specifically, the transformation of alachlor to 3,5-diethylbenzoquinone-4-imine was examined. A key intermediate in this pathway was identified as 2,...

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Bibliographic Details
Published in:	Drug metabolism and disposition Vol. 18; no. 3; p. 373
Main Authors:	Feng, P C, Wilson, A G, McClanahan, R H, Patanella, J E, Wratten, S J
Format:	Journal Article
Language:	English
Published:	United States 01-05-1990
Subjects:	Acetamides - metabolism Acetamides - pharmacokinetics Administration, Oral Aminopeptidases - metabolism Animals Autoradiography Biotransformation In Vitro Techniques Liver - enzymology Liver - metabolism Male Mice Nasal Mucosa - metabolism Oxidation-Reduction Rats Species Specificity Substrate Specificity Turbinates - metabolism
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