Ultrastructural study of selenite-induced nuclear cataracts

The formation of the selenite-induced cataract was investigated by examining the ultrastructure of the cataract with transmission electron microscopy (TEM). A lacy, or honeycomb, appearance of the nuclear cataract seen by light microscopy was resolved by TEM to be due to the aggregation or precipita...

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Bibliographic Details
Published in:	Investigative ophthalmology & visual science Vol. 25; no. 6; pp. 751 - 757
Main Authors:	Russell, NJ, Royland, JE, McCawley, EL, Shearer, TR
Format:	Journal Article
Language:	English
Published:	Bethesda, MD ARVO 01-06-1984 Association for Research in Vision and Ophtalmology
Subjects:	Animals Biological and medical sciences Cataract - chemically induced Cataract - pathology Lens diseases Medical sciences Microscopy, Electron Ophthalmology Rats Selenious Acid Selenium - adverse effects Vertebrata Cataract Experimental disease Mammalia Transmission electron microscopy Rat Rodentia Lens Injection Selenium
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Summary:	The formation of the selenite-induced cataract was investigated by examining the ultrastructure of the cataract with transmission electron microscopy (TEM). A lacy, or honeycomb, appearance of the nuclear cataract seen by light microscopy was resolved by TEM to be due to the aggregation or precipitation of cytoplasmic material. Despite severe intracellular changes the fibers retained their close apposition to one another. These results are consistent with the hypothesis that a major lesion in selenite-induced nuclear cataracts is the formation of insoluble cytoplasmic aggregates.
ISSN:	0146-0404 1552-5783