Comparison of Technetium-99m-HM-PAO Leukocytes with Indium-111-Oxine Leukocytes for Localizing Intraabdominal Sepsis

• Published in: The Journal of nuclear medicine (1978) Vol. 31; no. 3; pp. 311 - 315
• Main Authors: Mountford, Peter J, Kettle, Andrew G, O'Doherty, Michael J, Coakley, Anthony J
• Format: Journal Article
• Language: English
• Published: United States Soc Nuclear Med 01-03-1990
• Subjects: 550601 - Medicine- Unsealed Radionuclides in Diagnostics; ABDOMEN; Abdomen - diagnostic imaging; AROMATICS; AZAARENES; AZINES; BACTERIAL DISEASES; Bacterial Infections - diagnostic imaging; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY AREAS; BODY FLUIDS; COMPARATIVE EVALUATIONS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSIS; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; False Positive Reactions; Female; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; Humans; HYDROXY COMPOUNDS; Hydroxyquinolines; INDIUM 111; INDIUM ISOTOPES; Indium Radioisotopes; INFECTIOUS DISEASES; INTERMEDIATE MASS NUCLEI; ISOMERIC NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LEUKOCYTES; Male; MATERIALS; Middle Aged; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; Organometallic Compounds; Organotechnetium Compounds; Oximes; OXINE; Oxyquinoline - analogs & derivatives; PYRIDINES; QUINOLINES; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOLOGY AND NUCLEAR MEDICINE; Radionuclide Imaging; RADIOPHARMACEUTICALS; SENSITIVITY ANALYSIS; SPECIFICITY; TECHNETIUM 99; TECHNETIUM ISOTOPES; Technetium Tc 99m Exametazime; Time Factors; YEARS LIVING RADIOISOTOPES
• ISSN: 0161-5505; 1535-5667

Technetium-99m-HM-PAO [( 99mTc]HM-PAO) leukocyte and indium-111-oxine (111In-oxine) leukocyte scanning were carried out simultaneously in 41 patients at 4 hr and 24 hr after reinjection to determine whether the 4-hr 99mTc scan could replace the 24-hr 111In scan for detecting intraabdominal sepsis. Abdominal infection was confirmed in 12 cases. The 4-hr 99Tc-leukocyte scan, the 4-hr 111In-leukocyte scan, and the 24-hr 111In-leukocyte scan yielded a sensitivity of 100%, 67%, and 100%, respectively, and a specificity of 62%, 90%, and 86%, respectively. The 24-hr 99mTc-leukocyte scan also produced a sensitivity of 100%, but it was falsely positive in all 29 cases without infection due to physiologic bowel uptake. False-positive 4-hr 99mTc-leukocyte scans were also produced by physiologic bowel uptake in seven cases all of whom had true-negative 4-hr and 24-hr 111In-leukocyte scans. Because of the high incidence of false-positive 4-hr [99mTc]HM-PAO leukocyte scans, it was concluded that they could not replace 24-hr 111In-leukocyte scans for detecting intraabdominal sepsis, and that serial 99mTc leukocyte scans starting earlier than 4 hr after reinjection must be evaluated.