Copper Deficiency Myeloneuropathy Resembling B12 Deficiency: Partial Resolution of MR Imaging Findings with Copper Supplementation

• Published in: American journal of neuroradiology : AJNR Vol. 27; no. 10; pp. 2112 - 2114
• Main Authors: Goodman, B.P, Chong, B.W, Patel, A.C, Fletcher, G.P, Smith, B.E
• Format: Journal Article
• Language: English
• Published: Oak Brook, IL Am Soc Neuroradiology 01-11-2006; American Society of Neuroradiology
• Subjects: Biological and medical sciences; Copper - deficiency; Copper - therapeutic use; Diagnosis, Differential; Electrocardiography. Vectocardiography; Electrodiagnosis. Electric activity recording; Female; Fundamental and applied biological sciences. Psychology; Humans; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Medical sciences; Middle Aged; Nervous system; Perception; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Spinal Cord Diseases - diagnosis; Spinal Cord Diseases - drug therapy; Spine; Vision; Vitamin B 12 Deficiency - diagnosis; Nervous system diseases; Supplementation; Radiodiagnosis; Copper; Nuclear magnetic resonance imaging; Deficiency
• ISSN: 0195-6108; 1936-959X

Copper deficiency has been associated with a clinical syndrome, myeloneuropathy. Radiographic changes resembling B(12) deficiency in the cervical spinal cord have been described. We present a case of copper deficiency myeloneuropathy, with cervical MR imaging findings resembling B(12) deficiency, which partially reversed following copper supplementation. This is, to our knowledge, the first described case of radiographic improvement with copper supplementation.