Role of growth factor synthesis in the acquisition of insulin/insulin-like growth factor I independence in rat mammary carcinoma cells

In previous work, we demonstrated that a subset of carcinogen-induced rat mammary carcinomas consists of cells that are independent of growth factors strictly required by normal rat mammary epithelial (RME) cells for long-term growth in serum-free medium. Furthermore, only those tumors that expresse...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 50; no. 17; p. 5351
Main Authors:	Ethier, S P, Chiodino, C, Jones, R F
Format:	Journal Article
Language:	English
Published:	United States 01-09-1990
Subjects:	Animals Cell Division - drug effects Culture Media Growth Substances - biosynthesis Insulin - pharmacology Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - pharmacology Mammary Glands, Animal - cytology Mammary Glands, Animal - drug effects Mammary Glands, Animal - metabolism Mammary Neoplasms, Experimental - metabolism Poly A - genetics Poly A - isolation & purification Rats Receptors, Cell Surface - isolation & purification Receptors, Cell Surface - metabolism Receptors, Somatomedin RNA - genetics RNA - isolation & purification RNA, Messenger Somatomedins - pharmacology Transfection Tumor Cells, Cultured - cytology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism
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