Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells

Reduced glutathione and N-acetylcysteine can inhibit both apoptosis and necrosis of several cell types, suggesting a critical role for reactive oxygen species (ROS) in cell death. However, how the cellular defense against oxidative stress is connected with other cell death mediators remains unclear....

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Bibliographic Details
Published in:	Molecular pharmacology Vol. 60; no. 3; p. 488
Main Authors:	Gouazé, V, Mirault, M E, Carpentier, S, Salvayre, R, Levade, T, Andrieu-Abadie, N
Format:	Journal Article
Language:	English
Published:	United States 01-09-2001
Subjects:	Acetylcysteine - pharmacology Antimetabolites, Antineoplastic - pharmacology Antineoplastic Agents - pharmacology Apoptosis Breast Neoplasms - metabolism Breast Neoplasms - pathology Buthionine Sulfoximine - pharmacology Ceramides - metabolism Doxorubicin - pharmacology Drug Interactions Free Radical Scavengers - pharmacology Glutathione Peroxidase - metabolism Humans Reactive Oxygen Species - metabolism Signal Transduction Transfection Tumor Cells, Cultured
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