Different Actions of Deferoxamine and Iron on Ga-67 Abscess Detection in Rats

• Published in: The Journal of nuclear medicine (1978) Vol. 25; no. 6; pp. 668 - 672
• Main Authors: Oberhaensli, Rolf D, Mueller, Rita M, Fridrich, Raimund
• Format: Journal Article
• Language: English
• Published: United States Soc Nuclear Med 01-06-1984
• Subjects: Abscess - diagnostic imaging; Abscess - metabolism; Animals; Deferoxamine; Drug Evaluation, Preclinical; Female; Ferric Compounds; Gallium Radioisotopes - metabolism; Glucaric Acid; Iron - blood; Radionuclide Imaging; Rats; Rats, Inbred Strains; Time Factors; Tissue Distribution
• EISSN: 1535-5667
• ISSN: 0161-5505

The contrast-enhancing properties of iron (Fe) and deferoxamine (DFO) in abscess imaging with Ga-67 citrate were compared in rats bearing turpentine-induced abscesses. Iron administration shifted Ga-67 from plasma into tissues such as muscle and fat. As a result, the abscess-to-plasma ratio increased whereas the abscess-to-muscle ratio decreased. DFO enhanced the abscess-to-muscle and abscess-to-plasma ratios by increasing urinary Ga-67 excretion. In contrast to Fe, DFO removed abscess-bound Ga-67, thus representing a disadvantage of DFO compared with Fe. As a result, the abscess-to-plasma ratio was more effectively enhanced by Fe than by DFO. We conclude that abscess imaging with Ga-67 citrate may be improved by administration of Fe for detection of abscesses masked by blood activity, or DFO for detection of abscesses surrounded by muscle tissue.