Liarozole and 13-cis-retinoic acid anti-prostatic tumor activity

Liarozole fumarate (R85,246), a novel benzimidazole derivative, reduced s.c. and bone metastasis tumor growth by the androgen-independent PC-3ML-B2 human prostatic carcinoma clone in SCID mice. The drug inhibited cell invasion of Matrigel in Boyden chamber chemotactic assays and the secretion of typ...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 53; no. 13; pp. 3073 - 3077
Main Authors:	STEARNS, M. E, WANG, M, FUDGE, K
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 01-07-1993
Subjects:	Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Bone Neoplasms - prevention & control Bone Neoplasms - secondary Cell Adhesion - drug effects Cell Division - drug effects Cell Survival - drug effects Chemotactic Factors - pharmacology Chemotherapy Collagenases - drug effects Collagenases - secretion Disease Models, Animal Humans Imidazoles - administration & dosage Isotretinoin - administration & dosage Male Matrix Metalloproteinase 9 Medical sciences Mice Mice, SCID Neoplasm Invasiveness Neoplasm Transplantation Pharmacology. Drug treatments Prostatic Neoplasms - drug therapy Prostatic Neoplasms - enzymology Prostatic Neoplasms - pathology Tumor Cells, Cultured - drug effects Antineoplastic agent Human Drug combination Urinary system disease Androgen Rodentia Malignant tumor Prostatic disease In vivo Vertebrata Chemotherapy Experimental disease Mammalia Treatment Mouse Animal Drug interaction Sex steroid hormone Male genital diseases Prostate Retinoic acid
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