Detection of infectious centers in C57BL/Ka lymphoid cell populations infected in vitro by the radiation leukemia virus

The cocultivation of nonproducer lymphoma cells derived from a radiation-induced lymphoma of the C57BL/Ka mouse with cultures of lymphoid cell populations from the thymus, spleen, and marrow of the same strain 48 hr after their infection by the C57BL/Ka leukemia viruses permits the detection of infe...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 40; no. 3; pp. 544 - 549
Main Authors:	Boniver, J, Declève, A, Finn, O J, Honsik, C, Lieberman, M, Kaplan, H S
Format:	Journal Article
Language:	English
Published:	United States 01-03-1980
Subjects:	Animals Bone Marrow Cells Cell Survival Cells, Cultured Leukemia Virus, Murine - growth & development Leukemia, Experimental - microbiology Lymphocytes - microbiology Lymphoma - microbiology Mice Mice, Inbred C57BL - microbiology Spleen - cytology Thymus Gland - cytology Thymus Gland - microbiology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The cocultivation of nonproducer lymphoma cells derived from a radiation-induced lymphoma of the C57BL/Ka mouse with cultures of lymphoid cell populations from the thymus, spleen, and marrow of the same strain 48 hr after their infection by the C57BL/Ka leukemia viruses permits the detection of infectious centers in these cultures. A quantitative assay is described which allows the estimation in lymphoid cell subpopulations of the numbers of target cells susceptible to productive infection by the thymotropic and leukemogenic viruses of C57BL/Ka mice in vitro. This assay should greatly facilitate the identification and characterization of such target cells.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0008-5472