The effect of disorders of thrombocyte functional activity on the microcirculatory status in the lungs and on external respiratory function in patients with aspirin-induced asthma

• Published in: Terapevtic̆eskii arhiv Vol. 65; no. 3; p. 12
• Main Authors: Petrishchev, N N, Fedoseev, G V, Evsiukova, E V, Amosov, V I, Sinitsyna, T M, Amoashiĭ, G S
• Format: Journal Article
• Language: English; Russian
• Published: Russia (Federation) 1993
• Subjects: Adult; Aspirin - adverse effects; Asthma - chemically induced; Asthma - physiopathology; Blood Platelets - drug effects; Blood Platelets - physiology; Capillaries - drug effects; Capillaries - physiopathology; Convalescence; Humans; Lung - blood supply; Lung - drug effects; Male; Platelet Aggregation - drug effects; Platelet Aggregation - physiology; Respiration - drug effects; Respiration - physiology
• ISSN: 0040-3660

Platelet aggregation, pulmonary microcirculation and external respiration were studied against clinical appearance of the disease in 20 patients with aspirin-sensitive asthma (ASA) and 10 asthmatics without aspirin intolerance. All ASA patients were found to exhibit higher intensity and rate of platelet aggregation induced by ATP and heparin. Capillary pulmonary circulation in them was decreased 2-fold compared to nonaspirin asthma patients. All ASA cases had obstructive impairment of pulmonary ventilation in peripheral bronchi. The more serious were defects in platelet function, the more significant were microcirculatory and external respiratory alterations in ASA. Thus, it is evident that changes in platelet function play an important role in the genesis of pulmonary microcirculation and external respiration affections in ASA patients.