Development of Antibiotic Resistance Against Ureaplasma urealyticum Strains Isolated from Urogenital Samples/Urogenital Orneklerden Izole Edilen Ureaplasma urealyticum Suslarina Karsi Antibiyotik Direnc Gelisimi

• Published in: Journal of urological surgery Vol. 5; no. 1; p. 17
• Main Authors: Saracoglu, Musa, Eroglu, Askin, Divrik, Rauf Taner
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01-03-2018
• Subjects: Care and treatment; Diagnosis; Health aspects; Microbial drug resistance; Ureaplasma urealyticum; Urethritis
• ISSN: 2148-9580; 2148-9580
• DOI: 10.4274/jus.1722

Objective: To assess any change in the antibiotic sensitivity of Ureaplasma urealyticum strains isolated from urogenital samples in the course of time. Materials and Methods: Hospital records were retrospectively examined and cases with growth of U. urealyticum in urogenital samples in the years 2008 and 2013 were identified. Furthermore, the change in the course of time was examined by taking into consideration the cases we reported in 2001. Results: Higher rates of sensitivity against tetracycline and doxycycline were observed in 60 patients with isolated U. urealyticum. Higher rates of resistance against ofloxacin and ciprofloxacin were observed. A significant difference was found in resistance against antibiotics when the records of 2008 and 2013 were compared. A statistically significant increase was found in resistance against ofloxacin and ciprofloxacin when the records of 2001 were compared with the records of 2008 and 2013 (p<0.0005). Conclusion: U. urealyticum strains demonstrated high levels of resistance to quinolones. Resistance development is increasing in the course of time. Sensitivity against tetracycline and doxycycline has continued at high rates. It would be beneficial to consider these results during empirical treatment to be applied in cases ineligible for culturing. Keywords: Ureaplasma urealyticum, Resistance to quinolones, Urethritis Amaç: Ürogenital örneklerden izole edilen Ureaplasma urealyticum suslarinin antibiyotiklere karsi duyarliliklarinin zaman içerisinde degisip degismediginin degerlendirilmesidir. Gereç ve Yöntem: Hastane kayitlari retrospektif olarak incelenerek 2008 ve 2013 yillari içerisinde ürogenital örneklerde U. urealyticum üreyen olgular belirlenmistir. Ayrica 2001 yilinda teblig ettigimiz olgular göz önünde bulundurularak zaman içerisindeki degisim incelenmistir. Bulgular: U. urealyticum izole edilen 60 hastada tetrasiklin ve doksisikline karsi yüksek oranlarda duyarlilik gözlenmistir. Ofloksasin ve siprofloksasine karsi direncin yüksek oranlarda oldugu gözlenmistir. 2008 ve 2013 yillari karsilastirildiginda antibiyotiklere karsi direnç oranlarinda anlamli bir farklilik gözlenmemistir. 2001 yili kayitlari 2008 ve 2013 yillari kayitlari ile karsilastirildiginda ofloksasin ve siprofloksasine karsi direncin istatistiksel olarak anlamli bir sekilde arttigi gözlenmistir (p<0,0005). Sonuç: U. urealyticum suslari kinolonlara karsi yüksek oranda direnç göstermektedirler. Zaman içerisinde direnç gelisimi artmaktadir. Tetrasiklin ve doksisikline karsi duyarlilik yüksek oranlarda devam etmektedir. Kültür yapilamayan olgularda uygulanacak olan ampirik tedavide bu durumun göz önünde bulundurulmasi yararli olacaktir. Anahtar Kelimeler: Ureaplasma urealyticum, Kinolonlara direnç, Üretrit