Investigation of Added Value of Imaging Performed in a Prone Position to Standard [.sup.18]F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Staging in Patients with Breast Cancer/Meme Kanserli Hastalarda Evreleme icin Yapilan Standart [.sup.18]F-Florodeoksiglukoz Pozitron Emisyon Tomografi/Bilgisayarli Tomografi Goruntulemesine Yuzustu Pozisyonda Yapilan Goruntulemenin Katkisinin Arastirilmasi

• Published in: Molecular imaging and radionuclide therapy Vol. 31; no. 1; p. 23
• Main Authors: Erdogan, Ezgi Basak, Aydin, Mehmet
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01-02-2022
• Subjects: Breast cancer; CT imaging; Diagnosis; Methods; Patients; PET imaging; Positioning; Tumor staging; Turkey
• ISSN: 2146-1414
• DOI: 10.4274/mirt.galenos.2021.48343

Objectives: To investigate whether additional imaging in a prone position has any value to the supine whole-body 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) images by comparing the visual and quantitative data about a local disease in the breast and axilla for the initial staging of breast cancer (BC). Methods: In this study, a total of 91 female patients with the BC were studied. Both the supine and prone images were examined based on the axial diameter, number and location of the primary tumor, local invasion signs of the tumor, the number of axillary lymph nodes with a suspected metastasis, metabolic parameters of the primary tumor and axillary lymph nodes, and registration artifacts of the PET and CT images were evaluated individually. These findings were compared with the histopathological data obtained after a surgery. Results: In the evaluation of a supine and prone imaging, tumor diameter and metabolic tumor volume (MTV) values of the breast lesions were greater in the supine position than in the prone position. However, there was no significant difference found between the other metabolic parameters of a primary tumor and axilla in both positions. In the supine and prone images, accuracy for skin involvement was 84% and 91.3%, respectively. Conclusion: In our study, we observed that, obtaining additional images in the prone position does not significantly benefit the evaluation of a local disease. The average values of the primary tumor diameter and MTV in the prone position appear to be smaller than the one in the supine position. However, the prone imaging in the patients with a newly diagnosed BC may be beneficial in selected patients and may contribute to preventing the false-positive results especially in patients with a suspected skin involvement. Keywords: Breast cancer, positron emission tomography/computed tomography (PET/CT), [.sup.18]F-fluorodeoxyglucose ([.sup.18]F-FDG), prone position Amac: Meme kanserinin ilk evrelendirmesi icin yapilan goruntulemede, meme ve aksilladaki lokal hastalik hakkindaki gorsel ve niceliksel verileri karsilastirarak, pron pozisyonda bolgesel goruntulemenin, standart tum vucut [.sup.18]flor-florodeoksiglukoz pozitron emisyon tomografisi/bilgisayarli tomografi (PET/BT) goruntulerine ek katkisinin olup olmadigini arastirmak. Yontem: Doksan bir meme kanserli kadin hasta incelendi. Hem supin hem de pron goruntuler; aksiyal cap, primer tumorun sayisi ve yeri, tumorun lokal invazyon bulgulari, metastaz supheli aksiller lenf nodu sayisi, primer tumor ve aksillar lenf nodlarinin metabolik parametreleri ile, PET ve BT goruntulerinin fuzyon artefaktlari ayri ayri degerlendirildi. Bu bulgular ameliyat sonrasi elde edilen histopatolojik verilerle karsilastirildi. Bulgular: Meme lezyonlarinin tumor capi ve metabolik tumor hacmi (MTV) degerleri supin pozisyonda, pron pozisyona gore daha yuksekti. Bununla birlikte, her iki pozisyonda alinan goruntulerde primer tumor ve aksillanin diger metabolik parametreleri arasinda onemli bir fark yoktu. Supin ve pron goruntulerde deri tutulumunun dogrulugu sirasiyla %84 ve %91,3 idi. Sonuc: Calismamizda, pron pozisyonda ek goruntu almanin, lokal hastalik degerlendirmesine anlamli fayda saglamadigini gozlemledik. Pron pozisyonda primer tumor capi ve MTV'nin ortalama degerleri, sirtustu pozisyondakinden daha kucuk bulundu. Bununla birlikte, yeni tani almis meme kanseri hastalarinda, pron goruntuleme, secilmis hastalarda faydali olabilir ve ozellikle cilt tutulumu suphesi olan hastalarda yanlis pozitif sonuclarin onlenmesine katkida bulunabilir. Anahtar kelimeler: Meme kanseri, pozitron emisyon tomografisi/bilgisayarli tomografi (PET/BT), [.sup.18]F-florodeoksiglukoz ([.sup.18]F-FDG), pron pozisyonu