Pharmacological Properties of IJaeumgeonbi-Tang/I on Redox System and Stress-Related Hormones in Chronic Subjective Dizziness: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 15; no. 11
• Main Authors: Kim, Chan-young, Kim, Hyeong-Geug, Lee, Hye Won, Seol, In-Chan, Kim, Yoon-Sik, Choi, Hyung Il, Park, Miso S, Yoo, Ho-Ryong
• Format: Journal Article
• Language: English
• Published: MDPI AG 01-11-2022
• Subjects: Care and treatment; Dizziness; Evaluation; Medicine, Botanic; Medicine, Herbal; Pharmacology; South Korea
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph15111375

Jaeumgeonbi-Tang (JGT), a traditional herbal medicine, has been used to treat dizziness and vertigo in Korea and China for hundreds of years. The purpose of this study was to evaluate the pharmacological properties of JGT in chronic subjective dizziness (CSD) patients. A randomized, double-blind, parallel-group and placebo-controlled trial was performed with a total of 50 CSD patients. The patients were randomly assigned to one of two groups: JGT or placebo (n = 25 for each). All participants received the treatment (placebo or JGT, 24 g/day) for 4 weeks. We analyzed the serum levels of oxidative stressors, antioxidants, and stress hormones. Serum levels of lipid peroxidation, but not nitric oxide, were significantly decreased in the JGT group. JGT not only prevented the decline of serum total glutathione contents and total antioxidant capacity, but it also increased superoxide dismutase and catalase activities. Serum levels of stress hormones including cortisol, adrenaline, and serotonin were notably normalized by JGT treatment, but noradrenaline levels were not affected. Regarding the safety and tolerability of JGT, we found no allergic, adverse, or side effects in any of the participants. JGT showed beneficial effects on CSD patients by improving redox status and balancing psycho-emotional stress hormones.