Synthesis, Properties, and Biological Activity of N-AcylAnthranilic Acid Amides

Synthesis, Properties, and Biological Activity of N-AcylAnthranilic Acid Amides

N-Substituted 5-iodo(H)anthranilic acid amides were synthesized by acylation of 5-iodoanthranilic acid amide in benzene with heating and by alkylation of anthranilic acid amide at room temperature. The synthesized compounds were studied for analgesic and anti-inflammatory activity and acute toxicity...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal Vol. 48; no. 12; p. 791
Main Authors: Kurbatov, E. R, Korkodinova, L. M, Gol'dshtein, A. G, Yarygina, T. I, Mardanova, L. G, Botalova, A. S
Format: Journal Article
Language:English
Published: Springer 01-03-2015
Subjects:
Acylation
Amides
Analgesics
Diclofenac
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Summary:N-Substituted 5-iodo(H)anthranilic acid amides were synthesized by acylation of 5-iodoanthranilic acid amide in benzene with heating and by alkylation of anthranilic acid amide at room temperature. The synthesized compounds were studied for analgesic and anti-inflammatory activity and acute toxicity as compared with diclofenac sodium and sodium mefenamate. The search for new biologically active compounds among N-substituted 5-iodo(H)anthranilic acid amides was shown to be promising.
ISSN:0091-150X
DOI:10.1007/s11094-015-1197-9