Bioanalytical LC-QTOF/MS Method for a IN/I-phenylpiperazine Derivate : An Anxiolytic- and Antidepressant-like Prototype Drug Applied to Pharmacokinetic and Biodistribution Studies

The LQFM05 is a prototype drug designed for treatment of psychiatric disorders, such as schizophrenia, exhibiting anxiolytic- and antidepressant-like (12 or 24 µmol/kg) effects in classical behavioral tests. In order to evaluate its pharmacokinetic properties, a liquid chromatography method coupled...

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Bibliographic Details

Published in:	Pharmaceuticals (Basel, Switzerland) Vol. 16; no. 7
Main Authors:	Ramos, Ana Cláudia M, Rezende, Kênnia R, Teixeira, Carolina M, Fernandes, Aline R, Santos, Heloa, Machado, Rúbia Darc, Menegatti, Ricardo, Vaz, Boniek G, Chaves, Andréa R
Format:	Journal Article
Language:	English
Published:	MDPI AG 01-06-2023
Subjects:	Antianxiety agents Antidepressants Chemical properties Evaluation Pharmacokinetics Brazil
Online Access:	Get full text
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