Retinol-Binding Protein 4 Is Associated With Prediabetes in Adults From the General Population: The Cooperative Health Research in the Region of Augsburg (KORA) F4 Study

• Published in: Diabetes care Vol. 34; no. 7; pp. 1648 - 1650
• Main Authors: MEISINGER, Christa, RÜCKERT, Ina M, RATHMANN, Wolfgang, DÖRING, Angela, THORAND, Barbara, HUTH, Cornelia, KOWALL, Bernd, KOENIG, Wolfgang
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01-07-2011
• Subjects: Adult; Analysis; Biological and medical sciences; Dextrose; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Fasting - blood; Female; Germany - epidemiology; Glucose; Glucose Intolerance - blood; Glucose Intolerance - epidemiology; Humans; Insulin resistance; Male; Medical research; Medical sciences; Metabolic diseases; Middle Aged; Miscellaneous; Nutrition; Original Research; Prediabetic state; Prediabetic State - blood; Prediabetic State - epidemiology; Public health. Hygiene; Public health. Hygiene-occupational medicine; Retinol-Binding Proteins, Plasma - genetics; Studies; Germany; Human; Association; Nutrition; Health; Scientific research; Adult; Metabolic diseases; Adipokine; Retinol binding protein 4; Endocrinology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc11-0118

We examined the association between retinol-binding protein 4 (RBP4), a novel adipokine, and prediabetes (isolated impaired fasting glucose [i-IFG], isolated impaired glucose tolerance [i-IGT], and combined IFG and IGT) in men and women aged 32-81 years.
The analysis was based on 2,614 participants without previously diagnosed diabetes and those with newly diagnosed diabetes of the Cooperative Health Research in the Region of Augsburg (KORA) F4 Study, conducted from 2006 to 2008 in southern Germany. Plasma RBP4 was analyzed by immunonephelometry.
In logistic regression analysis, RBP4 levels in the fourth quartile versus the first quartile were significantly associated with prediabetes (i-IGT, i-IFG, and IFG/IGT; reference normal glucose tolerance) independent of known metabolic risk factors and lifestyle variables (odds ratio 1.63 [95% CI 1.17-2.27] after multivariable adjustment). Stratification by sex showed generally similar results.
RBP4 levels were associated with prediabetes in individuals from the general population. Prospective studies investigating the impact of RBP4 on the development of glucose intolerance are needed.