Phytochemistry Ibuprofen-like activity in extra-virgin olive oil

Newly pressed extra-virgin olive oil contains oleocanthal - a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a...

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Bibliographic Details
Published in:	Nature Vol. 437; no. 7055; pp. 45 - 46
Main Authors:	Breslin, Paul A. S, Beauchamp, Gary K, Keast, Russell S. J, Morel, Diane, Lin, Jianming, Pika, Jana, Han, Qiang, Lee, Chi-Ho, Smith, Amos B
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01-09-2005
Subjects:	Aldehydes - adverse effects Aldehydes - chemistry Aldehydes - isolation & purification Aldehydes - pharmacology Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Cyclooxygenase Cyclooxygenase Inhibitors - adverse effects Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - isolation & purification Cyclooxygenase Inhibitors - pharmacology Dietary Fats, Unsaturated - adverse effects Dietary Fats, Unsaturated - pharmacology Ibuprofen Ibuprofen - chemistry Ibuprofen - pharmacology Molecular Structure natural products Nonsteroidal antiinflammatory drugs Olea - chemistry Olive Oil Phenols - adverse effects Phenols - chemistry Phenols - isolation & purification Phenols - pharmacology Plant Oils - adverse effects Plant Oils - chemistry Plant Oils - pharmacology Prostaglandins Q1
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Summary:	Newly pressed extra-virgin olive oil contains oleocanthal - a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0028-0836 1476-4687
DOI:	10.1038/437045a