Iron Metal-Organic Frameworks MIL-88B and NH2-MIL-88B for the Loading and Delivery of the Gasotransmitter Carbon Monoxide

• Published in: Chemistry : a European journal Vol. 19; no. 21; pp. 6785 - 6790
• Main Authors: Ma, Mingyan, Noei, Heshmat, Mienert, Bernd, Niesel, Johanna, Bill, Eckhard, Muhler, Martin, Fischer, Roland A., Wang, Yuemin, Schatzschneider, Ulrich, Metzler-Nolte, Nils
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 17-05-2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Carbon monoxide; Carbon Monoxide - chemistry; Chemistry; Crystals; IR spectroscopy; Iron - chemistry; metal-organic frameworks; Microscopy, Electron, Scanning; microwave synthesis; Microwaves; nanostructures; Nanostructures - chemistry; Spectroscopy, Fourier Transform Infrared; Spectrum analysis
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201201743

Crystals of MIL‐88B‐Fe and NH2‐MIL‐88B‐Fe were prepared by a new rapid microwave‐assisted solvothermal method. High‐purity, spindle‐shaped crystals of MIL‐88B‐Fe with a length of about 2 μm and a diameter of 1 μm and needle‐shaped crystals of NH2‐MIL‐88B‐Fe with a length of about 1.5 μm and a diameter of 300 nm were produced with uniform size and excellent crystallinity. The possibility to reduce the as‐prepared frameworks and the chemical capture of carbon monoxide in these materials was studied by in situ ultrahigh vacuum Fourier‐transform infrared (UHV‐FTIR) spectroscopy and Mössbauer spectroscopy. CO binding occurs to unsaturated coordination sites (CUS). The release of CO from the as‐prepared materials was studied by a myoglobin assay in physiological buffer. The release of CO from crystals of MIL‐88B‐Fe with t1/2=38 min and from crystals of NH2‐MIL‐88B‐Fe with t1/2=76 min were found to be controlled by the degradation of the MIL materials under physiological conditions. These MIL‐88B‐Fe and NH2‐MIL‐88B‐Fe materials show good biocompatibility and have the potential to be used in pharmacological and therapeutic applications as carriers and delivery vehicles for the gasotransmitter carbon monoxide.
Send and deliver: Spindle‐shaped crystals of MIL‐88B‐Fe with a length of about 2 μm and a diameter of 1 μm and needle‐shaped crystals of NH2‐MIL‐88B‐Fe with a length of about 1.5 μm and a diameter of 300 nm were produced with uniform size and excellent crystallinity (see picture). These materials show good biocompatibility and have potential pharmacological and therapeutic applications as carriers and delivery vehicles for the gasotransmitter CO.