Radiation Dosimetry for Indium-111-Pentetreotide

• Published in: The Journal of nuclear medicine (1978) Vol. 38; no. 12; pp. 1919 - 1922
• Main Authors: Stabin, M.G, Kooij, P.P.M, Bakker, W.H, Inoue, T, Endo, K, Coveney, J, de Jong, R, Minegishi, A
• Format: Journal Article
• Language: English
• Published: Reston, VA Soc Nuclear Med 01-12-1997; Society of Nuclear Medicine
• Subjects: Adult; Applied radiobiology (equipment, dosimetry...); Biological and medical sciences; Biological effects of radiation; Child; Computer Simulation; Female; Fundamental and applied biological sciences. Psychology; Humans; Indium Radioisotopes - pharmacokinetics; Kidney - radiation effects; Male; Octreotide - analogs & derivatives; Octreotide - pharmacokinetics; Pentetic Acid - analogs & derivatives; Pentetic Acid - pharmacokinetics; Pregnancy; Radiation Dosage; Radiation Protection; Radiopharmaceuticals - pharmacokinetics; Tissue Distribution; Tissues, organs and organisms biophysics; Tomography, Emission-Computed, Single-Photon; Human; Absorbed dose; Radiolabelling; Pentetreotide; Peptide hormone; Central nervous system; Compartmental model; Distribution; Peptidergic receptor; Effective dose; Dosimetry; Kinetic parameter; Somatostatin; Brain (vertebrata); Iodine
• ISSN: 0161-5505; 1535-5667

We present radiation dose estimates for 111In-pentetreotide.
Kinetic data were gathered in 10 subjects at two different sites. A compartmental model was used to fit the data, including retention, in three major organs and excretion.
The data were consistent for the subjects at both sites. The organ receiving the highest dose was the kidneys (0.52 mGy/MBq); the effective dose equivalent was 0.1 mSv/MBq, and the effective dose was 0.073 mSv/MBq.
The results of this study provide the basis for evaluation of radiation safety of this drug.