Novel Transcriptional and DNA Methylation Abnormalities of SORT1 Gene in Non-Small Cell Lung Cancer

Sortilin is an important regulator with potential tumour-suppressor function by limiting EGFR signalling. In this study, we undertook a comprehensive expression analysis of sortilin transcript variants and the DNA methylation status of their corresponding promoters in human non-small cell carcinomas...

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Bibliographic Details
Published in:	Cancers Vol. 16; no. 11; p. 2154
Main Authors:	Acha-Sagredo, Amelia, Wilson, Cornelia M, Garcia Bediaga, Naiara, Kalirai, Helen, Davies, Michael P A, Coupland, Sarah E, Field, John K, Liloglou, Triantafillos
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 06-06-2024 MDPI
Subjects:	Alternative splicing Biobanks Cancer Cancer therapies Development and progression Disease management DNA methylation Epidermal growth factor receptors Epigenetics Exosomes Gene expression Genetic aspects Genetic transcription Health aspects Kinases Leukocytes Lung cancer Lung cancer, Non-small cell Membrane proteins Methylation Non-small cell lung carcinoma Oncology, Experimental Small cell lung carcinoma Tumors United Kingdom United Kingdom > UK non-small cell lung cancer DNA methylation sortilin splicing
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