Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto x Fisher 344 cross

Depression is a heritable disorder that is often precipitated by stress. Abnormalities of the stress-reactive hypothalamic-pituitary-adrenal (HPA) axis are also common in depressed patients. In animal models, the forced swim test (FST) is the most frequently used test of depressive-like behavior. We...

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Bibliographic Details

Published in:	Molecular psychiatry Vol. 8; no. 4; pp. 423 - 433
Main Authors:	Solberg, L C, Ahmadiyeh, N, Baum, A E, Vitaterna, M H, Takahashi, J S, Turek, F W, Redei, E E
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01-04-2003
Subjects:	Animals Chromosome Mapping Crosses, Genetic Depression - genetics Female Hydrocortisone - blood Hypothalamo-Hypophyseal System - physiology Male Pituitary-Adrenal System - physiology Rats Rats, Inbred F344 Rats, Inbred WKY Sex Characteristics Species Specificity Stress, Psychological - genetics
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