A new sodium channel α-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2

• Published in: Genomics (San Diego, Calif.) Vol. 36; no. 1; pp. 202 - 205
• Main Authors: BECKERS, M.-C, ERNST, E, BELCHER, S, HOWE, J, LEVENSON, R, GROS, P
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier 15-08-1996
• Subjects: Animals; Biological and medical sciences; Chromosome Mapping; Classical genetics, quantitative genetics, hybrids; Crosses, Genetic; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Multigene Family - genetics; Muridae; Mus spretus; Polymorphism, Restriction Fragment Length; Rabbits; Rats; Schwann Cells; Sodium Channels - genetics; Species Specificity; Vertebrata; Genetic mapping; Linkage; Rodentia; Nervous system; Ionic channel; Chromosome 2; Vertebrata; Mammalia; Gene; Sodium; Mouse; Schwann cell; Alpha-Peptide chain; Brain (vertebrata)
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1996.0447

We have used a total of 27 AXB/BXA recombinant inbred mouse strains to determine the chromosomal location of a newly identified gene encoding an alpha-subunit isoform of the sodium channel from Schwann cells, Scn9a. Linkage analysis established that Scn9a mapped to the proximal segment of mouse chromosome 2. The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus x C57BL/6J backcross indicates that Scn9a is very tightly linked to Scn1a (gene encoding the type I sodium channel alpha-subunit of the brain) and forms part of a cluster of four Scna genes located on mouse chromosome 2.