Differential muscarinic receptor binding of acetylcholinesterase inhibitors in rat brain, human brain and Chinese hamster ovary cells expressing human receptors

Displacement of muscarinic radioligands by the cholinesterase inhibitors parathion, paraoxon, physostigmine and phenyl saligenin cyclic phosphate was examined in rat cortex and brain stem, human cortex and brain stem, and in Chinese hamster ovary (CHO) cells expressing human M2 or M4 muscarinic acet...

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Bibliographic Details
Published in:	The Journal of pharmacology and experimental therapeutics Vol. 281; no. 3; p. 1113
Main Authors:	Van Den Beukel, I, Dijcks, F A, Vanderheyden, P, Vauquelin, G, Oortgiesen, M
Format:	Journal Article
Language:	English
Published:	United States 01-06-1997
Subjects:	Adult Aged Aged, 80 and over Animals Brain - drug effects CHO Cells Cholinesterase Inhibitors - pharmacology Cricetinae Dose-Response Relationship, Drug Humans Male Middle Aged Paraoxon - pharmacology Rats Rats, Wistar Receptors, Muscarinic - drug effects
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