Shuttle craft Gene Affects Lifespan of Drosophilamelanogaster by Controlling Early Development and Modifying Aging Program

• Published in: Biochemistry (Moscow) Vol. 87; no. 12-13; pp. 1611 - 1621
• Main Authors: Symonenko, Alexander V., Roshina, Natalia V., Krementsova, Anna V., Rybina, Olga Y., Pasyukova, Elena G.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-12-2022; Springer; Springer Nature B.V
• Subjects: Aging; Analysis; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Cell death; Drosophila; Excitotoxicity; Gene regulation; Genetic aspects; Genetic control; Genetic transcription; Growth; Life Sciences; Life span; Microbiology; Preventable deaths; Stc gene; Transcription factors; Russia; nervous system; transcription factors; lifespan; embryonic development; locomotion; aging; excitotoxicity; glutamate; phenoptosis
• ISSN: 0006-2979; 1608-3040
• DOI: 10.1134/S0006297922120161

Fundamental mechanisms underlying genetic control of lifespan are intensively studied and discussed due to the increasing importance of extending healthy human life. The
stc
gene of the model organism
Drosophila
melanogaster
encodes a transcription factor, homolog of the human transcription factor NF-X1, involved in regulation of neuronal development and other processes, as well as in control of lifespan. In this work, we demonstrate that the
stc
knockdown in embryonic and nerve cells leads to changes in lifespan, with the nature of changes depending on the cell type and sex of individuals. Based on our results, we suggest that
stc
gene is involved in transcription regulation throughout life, and, as a result, also affects a complex integral trait, lifespan. At the same time, we show that the reduction of
stc
expression in neurons can alleviate the negative effect of glutamate on longevity, possibly preventing development of glutamate excitotoxicity, thus modifying the cell death program and preventing death of individuals due to phenoptosis.